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First Principles

Breaking down complex problems from fundamentals
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RAG vs Fine-Tuning vs Context Windows: Which Architecture Actually Works for Clinical AI?

Devangshu on Healthcare AI, Blog, First Principles | 15 Mar 2026

Healthcare AI teams face a critical architecture decision: RAG, fine-tuning, or massive context windows? After shipping systems across clinical trials, drug discovery, and patient recruitment, here is what actually works in production.…

Building in Public: How I Automated My Entire Content Pipeline with AI Agents

Devangshu on Building in Public, Blog, First Principles | 10 Mar 2026

I built a system of AI agents that handles ideation, scripting, editing, and multi-platform publishing. Here's the architecture and what I learned.…

The First Principles of Healthcare AI Product Management

Devangshu on First Principles, Product Management, Blog | 25 Feb 2026

Most AI product frameworks break in healthcare. Here are the five principles that actually survive contact with regulators, clinicians, and real patients.…

Product Breakdown: How Tempus Uses AI to Personalize Cancer Treatment

Devangshu on Product Breakdown, Healthcare AI, First Principles | 08 Feb 2026

Dissecting Tempus's data-first approach to precision oncology — and why their moat isn't the AI.…

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